The chances of being diagnosed with Leaky Gut Syndrome are pretty remote. It does not even occur to many doctors to check for the condition. A further complication is that gut distress often manifests as disease in other parts of the body. Leaky Gut Syndrome is one of the most misunderstood concepts in modern medicine. This condition is associated with an abnormal increase in the permeability o...

The intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates the host from the environment. In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the blood stream creating a "leaky gut." In individuals with a genetic predisposition, a leaky gu...

Leaky Gut Syndrome is the name given to a very common health disorder in which the intestinal lining is more permeable than normal. The abnormally large spaces present between the cells of the gut wall allow the entry of toxic material into the bloodstream that would, in healthier circumstances, be repelled and eliminated. The gut becomes “leaky” in the sense that bacteria, viruses, fungi, para...

Abstract Giardia duodenalis is a common intestinal pathogen transmitted via consumption of contaminated water. In addition to causing distress symptoms, infection one the top 5 infectious causes growth stunting in children under two. Growth faltering complex pathology facilitated by changes barrier and enzymatic deficiencies. While widely associated with damage vitro, animal models, patient stu...

Asthma is a common respiratory disease characterized by airway inflammation, airway hyperreactivity, and reversible airflow obstruction. Despite current treatments, the prevalence of asthma has increased markedly over decades. According to the theories proposed to explain the pathophysiology of autoimmune diseases in integrative medicine, leaky gut syndrome is a phenomenon of increased intestin...

Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on the role of impaired intestinal barrier function on autoimmune pathogenesis. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junct...

BACKGROUND Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new...

In humans, the intestinal epithelium is a single layer of cells that constitutes one of the most important barriers between internal and external environments. The so-called ‘intestinal barrier’ (IB) is a dynamic structure composed of different types of cellular junctions that can be regulated by physiological and pathological stimuli, and act as a selective barrier to antigens and pathogens. P...